Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer

Abstract Background Most primary Triple Negative Breast Cancers (TNBCs) show amplification console housing of the Epidermal Growth Factor Receptor (EGFR) gene, leading to increased protein expression.However, unlike other EGFR-driven cancers, targeting this receptor in TNBC yields inconsistent therapeutic responses.Methods To elucidate the underlyi

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